KIDO ALFA

(Alfa Ketoanalogue – Nano Tablet)

Nitrogen-Free Protein Support for CKD

 PRODUCT INTRODUCTION

Brand Name: KIDO ALFA
Composition: Alfa Ketoanalogues of Essential Amino Acids (Nano Technology Tablet)

Category: Pre-Dialysis Renal Nutrition Therapy

CLINICAL BACKGROUND (FOR MR UNDERSTANDING)

Why Ketoanalogues in CKD?

In CKD Stage 3–5:

• Urea & creatinine increase
• Protein restriction advised
• Malnutrition risk increases
• Nitrogen load worsens uremia

👉 Patients need essential amino acids without nitrogen burden.

That is where Alfa Ketoanalogues play a critical role.

MODE OF ACTION (MOA)

🔹 Alfa Ketoanalogues

• Nitrogen-free analogues of essential amino acids
• Transaminated in body using circulating nitrogen
• Form essential amino acids
• Reduce urea formation
• Decrease nitrogenous waste load

Nano Tablet Advantage

• Better absorption
• Smaller tablet size
• Improved compliance
• Enhanced bioavailability

Overall Effect

✔ Lowers blood urea
✔ Reduces metabolic burden
✔ Delays progression to dialysis
✔ Prevents protein-energy wasting

INDICATIONS

• CKD Stage 3–5 (Pre-dialysis)
• Rising serum urea
• Low-protein diet patients
• Protein-energy malnutrition in CKD
• Diabetic nephropathy (advanced stage)

 DOSAGE

As prescribed by physician.
(Usually 1 tablet per 5 kg body weight per day in divided doses — as per standard ketoanalogue therapy.)

 FEATURE – ADVANTAGE – BENEFIT (FAB)

🔹 Feature

Nitrogen-free essential amino acid analogues (Nano technology)

🔹 Advantage

Reduces urea load while maintaining protein nutrition

🔹 Benefit

Delays dialysis initiation & preserves nutritional status

 USP (UNIQUE SELLING PROPOSITION)

✔ Nano tablet technology
✔ Better compliance
✔ Renal-stage specific therapy
✔ Ideal adjunct to low-protein diet
✔ Dialysis-delay positioning

 SAFETY PROFILE

• Generally well tolerated
• Hypercalcemia possible (monitor calcium)
• Must be used with protein-restricted diet
• Physician supervision required