MEGAFORD 160

(Megestrol Acetate 160 mg Tablet)

Appetite Restoration & Cachexia Management Therapy

 PRODUCT INTRODUCTION

Brand Name: MEGAFORD 160
Generic Name: Megestrol Acetate 160 mg
Category:Progestational Appetite Stimulant

CLINICAL BACKGROUND (FOR MR UNDERSTANDING)

Loss of appetite & weight loss common in:

• CKD patients
• Dialysis patients
• Cancer cachexia
• Elderly patients
• Chronic infections
• Post-surgery recovery

Malnutrition leads to:

• Muscle wasting
• Poor immunity
• Delayed recovery
• Poor quality of life

👉 Appetite stimulation improves overall prognosis.

MODE OF ACTION (MOA)

Megestrol Acetate is a synthetic progestin.

Mechanism:

• Stimulates appetite via hypothalamic action
• Increases neuropeptide Y
• Promotes weight gain
• Improves caloric intake
• Has anti-cachectic effect

Clinical Result:

✔ Increased appetite
✔ Weight gain
✔ Improved nutritional status
✔ Better treatment compliance

INDICATIONS

• Cancer cachexia
• CKD-related malnutrition
• Dialysis-related weight loss
• HIV-associated wasting
• Geriatric anorexia
• Chronic illness-related anorexia

DOSAGE

• 160 mg once daily
• Dose may vary as per indication
• As prescribed by physician

FEATURE – ADVANTAGE – BENEFIT (FAB)

🔹 Feature

Potent appetite stimulant (Progestational therapy)

🔹 Advantage

Stimulates central appetite pathways

🔹 Benefit

Improved weight, strength & recovery

USP

✔ Proven appetite stimulant
✔ Effective in cachexia
✔ Once-daily dosing
✔ Improves nutritional compliance
✔ Useful in CKD & oncology segment

 SAFETY PROFILE

• Possible weight gain
• Fluid retention (monitor in cardiac patients)
• Rare thromboembolic risk
• Monitor long-term use

Generally well tolerated under supervision.

1. Key positioning? → Appetite restoration therapy