ASTASEV 400
(Sevelamer Carbonate 400 mg)
Non-Calcium Phosphate Binder for Dialysis & CKD
PRODUCT INTRODUCTION
Brand Name: ASTASEV 400
Composition: Sevelamer Carbonate 400 mg
Category: Non-calcium Phosphate Binder
CLINICAL BACKGROUND (FOR MR UNDERSTANDING)
In CKD Stage 4–5 & Dialysis:
- Hyperphosphatemia develops
- Secondary hyperparathyroidism increases
- Vascular calcification risk rises
- Bone mineral disorder (CKD-MBD) worsens
Traditional calcium binders:
- Increase serum calcium
- Promote vascular calcification
👉 Sevelamer is calcium-free and safer for long-term control.
MODE OF ACTION (MOA)
- Non-absorbable polymer resin
- Binds dietary phosphate in GI tract
- Forms insoluble complex
- Excreted in feces
Clinical Effects:
✔ Reduces serum phosphate
✔ Controls PTH progression
✔ Lowers risk of vascular calcification
✔ May reduce LDL cholesterol
INDICATIONS
- Hyperphosphatemia in CKD
- Dialysis patients
- CKD-MBD management
- Patients with hypercalcemia on calcium binders
DOSAGE
- Usually taken with meals
- Dose adjusted according to serum phosphate
- As prescribed by nephrologist
FEATURE – ADVANTAGE – BENEFIT (FAB)
🔹 Feature
Calcium-free phosphate binder
🔹 Advantage
No added calcium load
🔹 Benefit
Reduced vascular calcification risk & safer long-term therapy
USP
✔Non-calcium formulation
✔ No systemic absorption
✔ Dual benefit (phosphate + lipid reduction)
✔ Preferred in hypercalcemia patients
SAFETY PROFILE
- GI discomfort (bloating, constipation)
- Rare bowel obstruction
- Monitor phosphate levels
- Not absorbed systemically
