ASTAMYCIN

(Fosfomycin Trometamol 3 g Sachet)

Single-Dose Advanced UTI Therapy

1️⃣ PRODUCT INTRODUCTION

Brand Name: ASTAMYCIN
Generic Name: Fosfomycin Trometamol 3 g Sachet
Category: Broad-Spectrum Urinary Antibiotic

CLINICAL BACKGROUND (FOR MR UNDERSTANDING)

UTI is very common in:

• Women
• Diabetic patients
• CKD patients
• Recurrent infection cases
• Catheterized patients

Challenges:

• Antibiotic resistance
• Poor compliance with multi-day therapy
• ESBL-producing organisms

👉 Fosfomycin offers convenient, single-dose therapy with broad coverage.

MODE OF ACTION (MOA)

Fosfomycin:

• Inhibits MurA enzyme
• Blocks early stage of bacterial cell wall synthesis
• Prevents peptidoglycan formation
• Bactericidal action

Unique Mechanism:

Different from beta-lactams → Useful in resistant strains.

Coverage:

✔ E. coli
✔ Enterococcus
✔ ESBL-producing organisms
✔ Common UTI pathogens

INDICATIONS

• Uncomplicated UTI
• Acute cystitis
• Recurrent UTI
• ESBL suspected UTI
• UTI in diabetics
• UTI in women

DOSAGE

• 3 g sachet single dose
• Dissolve in water
• Take on empty stomach (preferably at bedtime after bladder emptying)
• As prescribed by physician

FEATURE – ADVANTAGE – BENEFIT (FAB)

🔹 Feature

Single-dose oral therapy

🔹 Advantage

Improved compliance & broad coverage

🔹 Benefit

Quick symptom relief with convenience

USP

✔ Single-dose therapy
✔ Effective in resistant organisms
✔ High urinary concentration
✔ Safe in most patients
✔ Ideal for compliance improvement

SAFETY PROFILE

• Mild GI upset
• Headache rare
• Generally well tolerated

Safe in most adult patients