(Pantoprazole + Domperidone SR)

Advanced Acid Suppression & GI Protection Therapy

 PRODUCT INTRODUCTION

🔹 PANSTAF 40

Composition: Pantoprazole 40 mg
Category: Proton Pump Inhibitor (PPI)

🔹 PANSTAF DSR

Composition: Pantoprazole + Domperidone SR
Category: PPI + Prokinetic Combination.

 CLINICAL BACKGROUND (FOR MR UNDERSTANDING)

Acid-related disorders common in:

• CKD patients
• Polypharmacy patients
• NSAID users
• Stress gastritis
• GERD patients

Symptoms:

• Heartburn
• Epigastric pain
• Nausea
• Bloating
• Regurgitation

👉 Proper acid suppression improves compliance with chronic therapies.

 MODE OF ACTION (MOA)

🔹 Pantoprazole (Both Products)

• Irreversibly inhibits H⁺/K⁺ ATPase pump
• Blocks final step of acid secretion
• Reduces gastric acid production

Clinical Effects:

✔ Promotes ulcer healing
✔ Reduces GERD symptoms
✔ Prevents NSAID-induced ulcers

🔹 Domperidone (PANSTAF DSR)

• Dopamine D2 receptor antagonist
• Enhances gastric emptying
• Reduces nausea & vomiting

Combined Benefit (DSR):

✔ Acid suppression
✔ Prokinetic support
✔ Symptom relief in reflux + nausea

 INDICATIONS

PANSTAF 40

• GERD
• Peptic ulcer disease
• Gastritis
• NSAID-induced gastritis
• Stress ulcer prophylaxis

PANSTAF DSR

• GERD with nausea
• Functional dyspepsia
• Reflux with bloating
• Acid peptic disease with delayed gastric emptying

 DOSAGE

• Once daily before meals
• DSR usually before breakfast
• As prescribed by physician

 FEATURE – ADVANTAGE – BENEFIT (FAB)

PANSTAF 40

Feature: Potent proton pump inhibition
Advantage: Strong 24-hour acid suppression
Benefit: Faster symptom relief & ulcer healing

PANSTAF DSR

Feature: PPI + Prokinetic combination
Advantage: Acid control + motility improvement
Benefit: Complete symptom relief

 USP

PANSTAF 40

✔ Strong acid suppression
✔ Once-daily dosing
✔ Safe long-term use

PANSTAF DSR

✔ Dual mechanism
✔ Better relief in reflux with nausea
✔ Improved patient compliance

 

 SAFETY PROFILE

• Generally well tolerated
• Long-term use: monitor magnesium & B12
• Domperidone: use cautiously in cardiac risk patients
• Take before meals